Publications

  • Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment. Dyczynski, M., Vesterlund, M., Björklund, A.-C., Zachariadis, V., Janssen, J., Gallart-Ayala, H., Daskalaki, E., Wheelock, C.E., Lehtiö, J., Grandér, D., Tamm, K.P., Nilsson, R., Cell Death & Disease, Sep 2018
  • Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage. Matic, LP, Jesus Iglesias, M, Vesterlund, M, Lengquist, M, Hong, MG, Saieed, S, Sanchez-Rivera, L, Berg, M, Razuvaev, A, Kronqvist, M, Lund, K, Caidahl, K, Gillgren, P, Ponten, F, Uhlen, M, Schwenk, JM, Hansson, GK, Paulsson-Berne, G, Fagman, E, Roy, J, Hultgren, R, Bergström, G, Lehtiö, J, Odeberg, J, Hedin, U., JACC Basic to Translational Science, Aug 2018
  • Molecular profiles of oxyphilic and chief cell parathyroid adenoma. Lu, M, Kjellin, H, Fotouhi, O, Lee, L, Nilsson, IL, Haglund, F, Höög, A, Lehtiö, J, Larsson, C, Molecular and cellular endocrinology, Jul 2018
  • A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility. Wei, B, Jolma, A, Sahu, B, Orre, LM, Zhong, F, Zhu, F, Kivioja, T, Sur, I, Lehtiö, J, Taipale, M, Taipale, J, Nature biotechnology, Jul 2018
  • Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin. Johansson, HJ, Vallhov, H, Holm, T, Gehrmann, U, Andersson, A, Johansson, C, Blom, H, Carroni, M, Lehtiö, J, Scheynius, A, Scientific reports, Jun 2018
  • Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3. Schmidt, A, Marabita, F, Kiani, NA, Gross, CC, Johansson, HJ, Éliás, S, Rautio, S, Eriksson, M, Fernandes, SJ, Silberberg, G, Ullah, U, Bhatia, U, Lähdesmäki, H, Lehtiö, J, Gomez-Cabrero, D, Wiendl, H, Lahesmaa, R, Tegnér, J, BMC biology, May 2018
  • Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow. Zhu, Y, Orre, LM, Johansson, HJ, Huss, M, Boekel, J, Vesterlund, M, Fernandez-Woodbridge, A, Branca, RMM, Lehtiö, J, Nature communications, Mar 2018
  • MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling. Dzieran, J, Rodriguez Garcia, A, Westermark, UK, Henley, AB, Eyre Sánchez, E, Träger, C, Johansson, HJ, Lehtiö, J, Arsenian-Henriksson, M, Proceedings of the National Academy of Sciences of the United States of America, Feb 2018
  • A Common Peptidolytic Mechanism for Targeting Peptide Degradation in Mitochondria and Chloroplasts. Kmiec, B, Branca, RMM, Murcha, MW, Lehtiö, J, Glaser, E, Teixeira, PF, Molecular plant, Feb 2018
  • Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin. Teixeira, PF, Masuyer, G, Pinho, CM, Branca, RMM, Kmiec, B, Wallin, C, Wärmländer, SKTS, Berntsson, RP, Ankarcrona, M, Gräslund, A, Lehtiö, J, Stenmark, P, Glaser, E, Journal of molecular biology, Feb 2018
  • Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach. Bereczki, E, Branca, RM, Francis, PT, Pereira, JB, Baek, JH, Hortobágyi, T, Winblad, B, Ballard, C, Lehtiö, J, Aarsland, D, Brain : a journal of neurology, Feb 2018
  • Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications. Nassa, G, Giurato, G, Cimmino, G, Rizzo, F, Ravo, M, Salvati, A, Nyman, TA, Zhu, Y, Vesterlund, M, Lehtiö, J, Golino, P, Weisz, A, Tarallo, R, Scientific reports, Jan 2018
  • Normalization of mass spectrometry data (NOMAD). Murie, C, Sandri, B, Sandberg, AS, Griffin, TJ, Lehtiö, J, Wendt, C, Larsson, O, Advances in biological regulation, Jan 2018
  • Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema. Egaña, I, Kaito, H, Nitzsche, A, Becker, L, Ballester-Lopez, C, Niaudet, C, Petkova, M, Liu, W, Vanlandewijck, M, Vernaleken, A, Klopstock, T, Fuchs, H, Gailus-Durner, V, Hrabe de Angelis, M, Rask-Andersen, H, Johansson, HJ, Lehtiö, J, He, L, Yildirim, AÖ, Hellström, M, German Mouse Clinic Consortium, Scientific reports, Nov 2017
  • Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization. Zhao, M, Spiess, M, Johansson, HJ, Olofsson, H, Hu, J, Lehtiö, J, Strömblad, S, Oncotarget, Sep 2017
  • Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells. Reithmeier, A, Panizza, E, Krumpel, M, Orre, LM, Branca, RMM, Lehtiö, J, Ek-Rylander, B, Andersson, G, BMC cancer, Sep 2017
  • Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells. Azimi, A, Tuominen, R, Costa Svedman, F, Caramuta, S, Pernemalm, M, Frostvik Stolt, M, Kanter, L, Kharaziha, P, Lehtiö, J, Hertzman Johansson, C, Höiom, V, Hansson, J, Egyhazi Brage, S, Cell death & disease, Aug 2017
  • Tuning Metabolome Coverage in Reversed Phase LC-MS Metabolomics of MeOH Extracted Samples Using the Reconstitution Solvent Composition. Lindahl, A, Sääf, S, Lehtiö, J, Nordström, A, Analytical chemistry, Jul 2017
  • Isoelectric point-based fractionation by HiRIEF coupled to LC-MS allows for in-depth quantitative analysis of the phosphoproteome. Panizza, E, Branca, RMM, Oliviusson, P, Orre, LM, Lehtiö, J, Scientific reports, Jul 2017
  • Comparative proteomics reveals signature metabolisms of exponentially growing and stationary phase marine bacteria. Muthusamy, S, Lundin, D, Mamede Branca, RM, Baltar, F, González, JM, Lehtiö, J, Pinhassi, J, Environmental microbiology, Jun 2017
  • Discrimination of pancreatic cancer and pancreatitis by LC-MS metabolomics. Lindahl, A, Heuchel, R, Forshed, J, Lehtiö, J, Löhr, M, Nordström, A, Metabolomics : Official journal of the Metabolomic Society, Apr 2017
  • Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis. Zhu, Y, Engström, PG, Tellgren-Roth, C, Baudo, CD, Kennell, JC, Sun, S, Billmyre, RB, Schröder, MS, Andersson, A, Holm, T, Sigurgeirsson, B, Wu, G, Sankaranarayanan, SR, Siddharthan, R, Sanyal, K, Lundeberg, J, Nystedt, B, Boekhout, T, Dawson, TL, Heitman, J, Scheynius, A, Lehtiö, J, Nucleic acids research, Mar 2017
  • Optimizing Analytical Depth and Cost Efficiency of IEF-LC/MS Proteomics. Kifer, I, Branca, RM, Ben-Dor, A, Zhai, L, Xu, P, Lehtio, J, Yakhini, Z, IEEE/ACM transactions on computational biology and bioinformatics, Mar 2017
  • A multi-step peptidolytic cascade for amino acid recovery in chloroplasts. Teixeira, PF, Kmiec, B, Branca, RM, Murcha, MW, Byzia, A, Ivanova, A, Whelan, J, Drag, M, Lehtiö, J, Glaser, E, Nature chemical biology, Jan 2017
  • Validation and development of MTH1 inhibitors for treatment of cancer. Warpman Berglund, U, Sanjiv, K, Gad, H, Kalderén, C, Koolmeister, T, Pham, T, Gokturk, C, Jafari, R, Maddalo, G, Seashore-Ludlow, B, Chernobrovkin, A, Manoilov, A, Pateras, IS, Rasti, A, Jemth, AS, Almlöf, I, Loseva, O, Visnes, T, Einarsdottir, BO, Gaugaz, FZ, Saleh, A, Platzack, B, Wallner, OA, Vallin, KS, Henriksson, M, Wakchaure, P, Borhade, S, Herr, P, Kallberg, Y, Baranczewski, P, Homan, EJ, Wiita, E, Nagpal, V, Meijer, T, Schipper, N, Rudd, SG, Bräutigam, L, Lindqvist, A, Filppula, A, Lee, TC, Artursson, P, Nilsson, JA, Gorgoulis, VG, Lehtiö, J, Zubarev, RA, Scobie, M, Helleday, T, Annals of oncology : official journal of the European Society for Medical Oncology, Dec 2016
  • Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves. Maleki, S, Kjellqvist, S, Paloschi, V, Magné, J, Branca, RM, Du, L, Hultenby, K, Petrini, J, Fuxe, J, MIBAVA Leducq Consortium, Lehtiö, J, Franco-Cereceda, A, Eriksson, P, Björck, HM, Scientific reports, Oct 2016
  • Proteomics Suggests a Role for APC-Survivin in Response to Somatostatin Analog Treatment of Neuroendocrine Tumors. Fotouhi, O, Kjellin, H, Larsson, C, Hashemi, J, Barriuso, J, Juhlin, CC, Lu, M, Höög, A, Pastrián, LG, Lamarca, A, Soto, VH, Zedenius, J, Mendiola, M, Lehtiö, J, Kjellman, M, The Journal of clinical endocrinology and metabolism, Oct 2016
  • Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. Perisic Matic, L, Rykaczewska, U, Razuvaev, A, Sabater-Lleal, M, Lengquist, M, Miller, CL, Ericsson, I, Röhl, S, Kronqvist, M, Aldi, S, Magné, J, Paloschi, V, Vesterlund, M, Li, Y, Jin, H, Diez, MG, Roy, J, Baldassarre, D, Veglia, F, Humphries, SE, de Faire, U, Tremoli, E, Odeberg, J, Vukojević, V, Lehtiö, J, Maegdefessel, L, Ehrenborg, E, Paulsson-Berne, G, Hansson, GK, Lindeman, JH, Eriksson, P, Quertermous, T, Hamsten, A, Hedin, U, Arteriosclerosis, thrombosis, and vascular biology, Sep 2016
  • Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression. Ivanov, M, Kals, M, Lauschke, V, Barragan, I, Ewels, P, Käller, M, Axelsson, T, Lehtiö, J, Milani, L, Ingelman-Sundberg, M, Nucleic acids research, Aug 2016
  • In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome. Simonson, OE, Mougiakakos, D, Heldring, N, Bassi, G, Johansson, HJ, Dalén, M, Jitschin, R, Rodin, S, Corbascio, M, El Andaloussi, S, Wiklander, OP, Nordin, JZ, Skog, J, Romain, C, Koestler, T, Hellgren-Johansson, L, Schiller, P, Joachimsson, PO, Hägglund, H, Mattsson, M, Lehtiö, J, Faridani, OR, Sandberg, R, Korsgren, O, Krampera, M, Weiss, DJ, Grinnemo, KH, Le Blanc, K, Stem cells translational medicine, Jun 2016
  • Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma. Wang, N, Kjellin, H, Sofiadis, A, Fotouhi, O, Juhlin, CC, Bäckdahl, M, Zedenius, J, Xu, D, Lehtiö, J, Larsson, C, Oncotarget, Apr 2016
  • Alterations in the membrane-associated proteome fraction of alveolar macrophages in sarcoidosis. Kjellin, H, Silva, E, Branca, RM, Eklund, A, Jakobsson, PJ, Grunewald, J, Lehtiö, J, Wheelock, ÅM, Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, Mar 2016
  • Cells release subpopulations of exosomes with distinct molecular and biological properties. Willms, E, Johansson, HJ, Mäger, I, Lee, Y, Blomberg, KE, Sadik, M, Alaarg, A, Smith, CI, Lehtiö, J, El Andaloussi, S, Wood, MJ, Vader, P, Scientific reports, Mar 2016
  • Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling. Anderson, JD, Johansson, HJ, Graham, CS, Vesterlund, M, Pham, MT, Bramlett, CS, Montgomery, EN, Mellema, MS, Bardini, RL, Contreras, Z, Hoon, M, Bauer, G, Fink, KD, Fury, B, Hendrix, KJ, Chedin, F, El-Andaloussi, S, Hwang, B, Mulligan, MS, Lehtiö, J, Nolta, JA, Stem cells (Dayton, Ohio), Mar 2016
  • Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration. Roberts, TC, Johansson, HJ, McClorey, G, Godfrey, C, Blomberg, KE, Coursindel, T, Gait, MJ, Smith, CI, Lehtiö, J, El Andaloussi, S, Wood, MJ, Human molecular genetics, Dec 2015
  • Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor. Griese, JJ, Kositzki, R, Schrapers, P, Branca, RM, Nordström, A, Lehtiö, J, Haumann, M, Högbom, M, The Journal of biological chemistry, Oct 2015
  • Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages. Vogt, C, Pernemalm, M, Kohonen, P, Laurent, S, Hultenby, K, Vahter, M, Lehtiö, J, Toprak, MS, Fadeel, B, PloS one, Oct 2015
  • In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome. Simonson, OE, Mougiakakos, D, Heldring, N, Bassi, G, Johansson, HJ, Dalén, M, Jitschin, R, Rodin, S, Corbascio, M, El Andaloussi, S, Wiklander, OP, Nordin, JZ, Skog, J, Romain, C, Koestler, T, Hellgren-Johansson, L, Schiller, P, Joachimsson, PO, Hägglund, H, Mattsson, M, Lehtiö, J, Faridani, OR, Sandberg, R, Korsgren, O, Krampera, M, Weiss, DJ, Grinnemo, KH, Le Blanc, K, Stem cells translational medicine, Oct 2015
  • Identifying and Assessing Interesting Subgroups in a Heterogeneous Population. Lee, W, Alexeyenko, A, Pernemalm, M, Guegan, J, Dessen, P, Lazar, V, Lehtiö, J, Pawitan, Y, BioMed research international, Aug 2015
  • Secretome protein signature of human gastrointestinal stromal tumor cells. Berglund, E, Daré, E, Branca, RM, Akcakaya, P, Fröbom, R, Berggren, PO, Lui, WO, Larsson, C, Zedenius, J, Orre, L, Lehtiö, J, Kim, J, Bränström, R, Experimental cell research, Aug 2015
  • Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles. Li, J, Lee, Y, Johansson, HJ, Mäger, I, Vader, P, Nordin, JZ, Wiklander, OP, Lehtiö, J, Wood, MJ, Andaloussi, SE, Journal of extracellular vesicles, May 2015
  • Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions. Dinets, A, Pernemalm, M, Kjellin, H, Sviatoha, V, Sofiadis, A, Juhlin, CC, Zedenius, J, Larsson, C, Lehtiö, J, Höög, A, PloS one, May 2015
  • Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties. Nordin, JZ, Lee, Y, Vader, P, Mäger, I, Johansson, HJ, Heusermann, W, Wiklander, OP, Hällbrink, M, Seow, Y, Bultema, JJ, Gilthorpe, J, Davies, T, Fairchild, PJ, Gabrielsson, S, Meisner-Kober, NC, Lehtiö, J, Smith, CI, Wood, MJ, El Andaloussi, S, Nanomedicine : nanotechnology, biology, and medicine, May 2015
  • RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. Goel, S, Palmkvist, M, Moll, K, Joannin, N, Lara, P, Akhouri, RR, Moradi, N, Öjemalm, K, Westman, M, Angeletti, D, Kjellin, H, Lehtiö, J, Blixt, O, Ideström, L, Gahmberg, CG, Storry, JR, Hult, AK, Olsson, ML, von Heijne, G, Nilsson, I, Wahlgren, M, Nature medicine, Apr 2015
  • Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine. Stäubert, C, Bhuiyan, H, Lindahl, A, Broom, OJ, Zhu, Y, Islam, S, Linnarsson, S, Lehtiö, J, Nordström, A, The Journal of biological chemistry, Mar 2015
  • Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer. Johansson, HJ, Sanchez, BC, Forshed, J, Stål, O, Fohlin, H, Lewensohn, R, Hall, P, Bergh, J, Lehtiö, J, Linderholm, BK, Clinical proteomics, Mar 2015
  • An overview of polyurethane foams in higher specification foam mattresses. Soppi, E, Lehtiö, J, Saarinen, H, Ostomy/wound management, Feb 2015
  • Multi-omic data analysis using Galaxy. Boekel, J, Chilton, JM, Cooke, IR, Horvatovich, PL, Jagtap, PD, Käll, L, Lehtiö, J, Lukasse, P, Moerland, PD, Griffin, TJ, Nature biotechnology, Feb 2015
  • Investigating the applicability of antibodies generated within the human protein atlas as capture agents in immunoenrichment coupled to mass spectrometry. Boström, T, Johansson, HJ, Lehtiö, J, Uhlén, M, Hober, S, Journal of proteome research, Oct 2014
  • Mass spectrometry-based plasma proteomics: state of the art and future outlook. Pernemalm, M, Lehtiö, J, Expert review of proteomics, Aug 2014
  • SpliceVista, a tool for splice variant identification and visualization in shotgun proteomics data. Zhu, Y, Hultin-Rosenberg, L, Forshed, J, Branca, RM, Orre, LM, Lehtiö, J, Molecular & cellular proteomics : MCP, Jun 2014
  • Immunoproteomics using polyclonal antibodies and stable isotope-labeled affinity-purified recombinant proteins. Edfors, F, Boström, T, Forsström, B, Zeiler, M, Johansson, H, Lundberg, E, Hober, S, Lehtiö, J, Mann, M, Uhlen, M, Molecular & cellular proteomics : MCP, Jun 2014
  • Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance. Azimi, A, Pernemalm, M, Frostvik Stolt, M, Hansson, J, Lehtiö, J, Egyházi Brage, S, Hertzman Johansson, C, British journal of cancer, May 2014
  • Proteome screening of pleural effusions identifies galectin 1 as a diagnostic biomarker and highlights several prognostic biomarkers for malignant mesothelioma. Mundt, F, Johansson, HJ, Forshed, J, Arslan, S, Metintas, M, Dobra, K, Lehtiö, J, Hjerpe, A, Molecular & cellular proteomics : MCP, Mar 2014
  • Differentially expressed proteins in malignant and benign adrenocortical tumors. Kjellin, H, Johansson, H, Höög, A, Lehtiö, J, Jakobsson, PJ, Kjellman, M, PloS one, Feb 2014
  • Quantitative accuracy in mass spectrometry based proteomics of complex samples: the impact of labeling and precursor interference. Sandberg, A, Branca, RM, Lehtiö, J, Forshed, J, Journal of proteomics, Jan 2014
  • HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics. Branca, RM, Orre, LM, Johansson, HJ, Granholm, V, Huss, M, Pérez-Bercoff, Å, Forshed, J, Käll, L, Lehtiö, J, Nature methods, Jan 2014
  • S100A4 interacts with p53 in the nucleus and promotes p53 degradation. Orre, LM, Panizza, E, Kaminskyy, VO, Vernet, E, Gräslund, T, Zhivotovsky, B, Lehtiö, J, Oncogene, Dec 2013
  • Integrated molecular portrait of non-small cell lung cancers. Lazar, V, Suo, C, Orear, C, van den Oord, J, Balogh, Z, Guegan, J, Job, B, Meurice, G, Ripoche, H, Calza, S, Hasmats, J, Lundeberg, J, Lacroix, L, Vielh, P, Dufour, F, Lehtiö, J, Napieralski, R, Eggermont, A, Schmitt, M, Cadranel, J, Besse, B, Girard, P, Blackhall, F, Validire, P, Soria, JC, Dessen, P, Hansson, J, Pawitan, Y, BMC medical genomics, Dec 2013
  • Selectivity analysis of single binder assays used in plasma protein profiling. Neiman, M, Fredolini, C, Johansson, H, Lehtiö, J, Nygren, PÅ, Uhlén, M, Nilsson, P, Schwenk, JM, Proteomics, Dec 2013
  • Direct observation of structurally encoded metal discrimination and ether bond formation in a heterodinuclear metalloprotein. Griese, JJ, Roos, K, Cox, N, Shafaat, HS, Branca, RM, Lehtiö, J, Gräslund, A, Lubitz, W, Siegbahn, PE, Högbom, M, Proceedings of the National Academy of Sciences of the United States of America, Oct 2013
  • Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts. Kmiec, B, Teixeira, PF, Berntsson, RP, Murcha, MW, Branca, RM, Radomiljac, JD, Regberg, J, Svensson, LM, Bakali, A, Langel, U, Lehtiö, J, Whelan, J, Stenmark, P, Glaser, E, Proceedings of the National Academy of Sciences of the United States of America, Oct 2013
  • Quantitative proteomics profiling of primary lung adenocarcinoma tumors reveals functional perturbations in tumor metabolism. Pernemalm, M, De Petris, L, Branca, RM, Forshed, J, Kanter, L, Soria, JC, Girard, P, Validire, P, Pawitan, Y, van den Oord, J, Lazar, V, Påhlman, S, Lewensohn, R, Lehtiö, J, Journal of proteome research, Sep 2013
  • Defining, comparing, and improving iTRAQ quantification in mass spectrometry proteomics data. Hultin-Rosenberg, L, Forshed, J, Branca, RM, Lehtiö, J, Johansson, HJ, Molecular & cellular proteomics : MCP, Jul 2013
  • MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells. Zirath, H, Frenzel, A, Oliynyk, G, Segerström, L, Westermark, UK, Larsson, K, Munksgaard Persson, M, Hultenby, K, Lehtiö, J, Einvik, C, Påhlman, S, Kogner, P, Jakobsson, PJ, Henriksson, MA, Proceedings of the National Academy of Sciences of the United States of America, Jun 2013
  • Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease. Tang, Z, Bereczki, E, Zhang, H, Wang, S, Li, C, Ji, X, Branca, RM, Lehtiö, J, Guan, Z, Filipcik, P, Xu, S, Winblad, B, Pei, JJ, The Journal of biological chemistry, May 2013
  • A combined proteomic and transcriptomic approach shows diverging molecular mechanisms in thoracic aortic aneurysm development in patients with tricuspid- and bicuspid aortic valve. Kjellqvist, S, Maleki, S, Olsson, T, Chwastyniak, M, Branca, RM, Lehtiö, J, Pinet, F, Franco-Cereceda, A, Eriksson, P, Molecular & cellular proteomics : MCP, Feb 2013
  • A novel prefractionation method combining protein and peptide isoelectric focusing in immobilized pH gradient strips. Pernemalm, M, Lehtiö, J, Journal of proteome research, Feb 2013
  • Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis. Gioti, A, Nystedt, B, Li, W, Xu, J, Andersson, A, Averette, AF, Münch, K, Wang, X, Kappauf, C, Kingsbury, JM, Kraak, B, Walker, LA, Johansson, HJ, Holm, T, Lehtiö, J, Stajich, JE, Mieczkowski, P, Kahmann, R, Kennell, JC, Cardenas, ME, Lundeberg, J, Saunders, CW, Boekhout, T, Dawson, TL, Munro, CA, de Groot, PW, Butler, G, Heitman, J, Scheynius, A, mBio, Jan 2013
  • Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Johansson, HJ, Sanchez, BC, Mundt, F, Forshed, J, Kovacs, A, Panizza, E, Hultin-Rosenberg, L, Lundgren, B, Martens, U, Máthé, G, Yakhini, Z, Helou, K, Krawiec, K, Kanter, L, Hjerpe, A, Stål, O, Linderholm, BK, Lehtiö, J, Nature communications, Jan 2013
  • In vitro oxidative inactivation of human presequence protease (hPreP). Teixeira, PF, Pinho, CM, Branca, RM, Lehtiö, J, Levine, RL, Glaser, E, Free radical biology & medicine, Dec 2012
  • Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model. Amano, M, Eriksson, H, Manning, JC, Detjen, KM, André, S, Nishimura, S, Lehtiö, J, Gabius, HJ, The FEBS journal, Nov 2012
  • Network enrichment analysis: extension of gene-set enrichment analysis to gene networks. Alexeyenko, A, Lee, W, Pernemalm, M, Guegan, J, Dessen, P, Lazar, V, Lehtiö, J, Pawitan, Y, BMC bioinformatics, Sep 2012
  • Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes. Sandberg, A, Lindell, G, Källström, BN, Branca, RM, Danielsson, KG, Dahlberg, M, Larson, B, Forshed, J, Lehtiö, J, Molecular & cellular proteomics : MCP, Jul 2012
  • Thapsigargin down-regulates protein levels of GRP78/BiP in INS-1E cells. Rosengren, V, Johansson, H, Lehtiö, J, Fransson, L, Sjöholm, A, Ortsäter, H, Journal of cellular biochemistry, May 2012
  • Proteomic profiling of follicular and papillary thyroid tumors. Sofiadis, A, Becker, S, Hellman, U, Hultin-Rosenberg, L, Dinets, A, Hulchiy, M, Zedenius, J, Wallin, G, Foukakis, T, Höög, A, Auer, G, Lehtiö, J, Larsson, C, European journal of endocrinology, Apr 2012
  • Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. Arabi, A, Ullah, K, Branca, RM, Johansson, J, Bandarra, D, Haneklaus, M, Fu, J, Ariës, I, Nilsson, P, Den Boer, ML, Pokrovskaja, K, Grandér, D, Xiao, G, Rocha, S, Lehtiö, J, Sangfelt, O, Nature communications, Jan 2012
  • Enhanced information output from shotgun proteomics data by protein quantification and peptide quality control (PQPQ). Forshed, J, Johansson, HJ, Pernemalm, M, Branca, RM, Sandberg, A, Lehtiö, J, Molecular & cellular proteomics : MCP, Oct 2011
  • Penicillin-binding protein 5 can form a homo-oligomeric complex in the inner membrane of Escherichia coli. Skoog, K, Bruzell, FS, Ducroux, A, Hellberg, M, Johansson, H, Lehtiö, J, Högbom, M, Daley, DO, Protein science : a publication of the Protein Society, Sep 2011
  • Identification of chromatophore membrane protein complexes formed under different nitrogen availability conditions in Rhodospirillum rubrum. Selao, TT, Branca, R, Chae, PS, Lehtiö, J, Gellman, SH, Rasmussen, SG, Nordlund, S, Norén, A, Journal of proteome research, Jun 2011
  • Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor. Ståhl, S, Branca, RM, Efazat, G, Ruzzene, M, Zhivotovsky, B, Lewensohn, R, Viktorsson, K, Lehtiö, J, Journal of proteome research, May 2011
  • Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo. Andaloussi, SE, Lehto, T, Mäger, I, Rosenthal-Aizman, K, Oprea, II, Simonson, OE, Sork, H, Ezzat, K, Copolovici, DM, Kurrikoff, K, Viola, JR, Zaghloul, EM, Sillard, R, Johansson, HJ, Said Hassane, F, Guterstam, P, Suhorutšenko, J, Moreno, PM, Oskolkov, N, Hälldin, J, Tedebark, U, Metspalu, A, Lebleu, B, Lehtiö, J, Smith, CI, Langel, U, Nucleic acids research, May 2011
  • Systematic analysis of native membrane protein complexes in Escherichia coli. Maddalo, G, Stenberg-Bruzell, F, Götzke, H, Toddo, S, Björkholm, P, Eriksson, H, Chovanec, P, Genevaux, P, Lehtiö, J, Ilag, LL, Daley, DO, Journal of proteome research, Apr 2011
  • Observed peptide pI and retention time shifts as a result of post-translational modifications in multidimensional separations using narrow-range IPG-IEF. Lengqvist, J, Eriksson, H, Gry, M, Uhlén, K, Björklund, C, Bjellqvist, B, Jakobsson, PJ, Lehtiö, J, Amino acids, Feb 2011
  • Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer. De Petris, L, Brandén, E, Herrmann, R, Sanchez, BC, Koyi, H, Linderholm, B, Lewensohn, R, Linder, S, Lehtiö, J, European journal of cancer (Oxford, England : 1990), Jan 2011
  • Vascular endothelial growth factor receptor 2 and downstream p38 mitogen-activated protein kinase are possible candidate markers of intrinsic resistance to adjuvant endocrine treatment in steroid receptor positive breast cancer. Linderholm, BK, Hellborg, H, Johansson, U, Skoog, L, Lehtiö, J, Breast cancer research and treatment, Jan 2011
  • Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma. Sofiadis, A, Dinets, A, Orre, LM, Branca, RM, Juhlin, CC, Foukakis, T, Wallin, G, Höög, A, Hulchiy, M, Zedenius, J, Larsson, C, Lehtiö, J, Thyroid : official journal of the American Thyroid Association, Oct 2010
  • Multivariate meta-analysis of proteomics data from human prostate and colon tumours. Rosenberg, LH, Franzén, B, Auer, G, Lehtiö, J, Forshed, J, BMC bioinformatics, Sep 2010
  • Lung cancer proteomics, clinical and technological considerations. Lehtiö, J, De Petris, L, Journal of proteomics, Sep 2010
  • A novel method for sample preparation of fresh lung cancer tissue for proteomics analysis by tumor cell enrichment and removal of blood contaminants. De Petris, L, Pernemalm, M, Elmberger, G, Bergman, P, Orre, L, Lewensohn, R, Lehtiö, J, Proteome science, Feb 2010
  • A comparison between protein profiles of B cell subpopulations and mantle cell lymphoma cells. Stranneheim, H, Orre, LM, Lehtiö, J, Flygare, J, Proteome science, Nov 2009
  • N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1. Jitkaew, S, Trebinska, A, Grzybowska, E, Carlsson, G, Nordström, A, Lehtiö, J, Fröjmark, AS, Dahl, N, Fadeel, B, The Journal of biological chemistry, Oct 2009
  • Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast cancer. Linderholm, BK, Hellborg, H, Johansson, U, Elmberger, G, Skoog, L, Lehtiö, J, Lewensohn, R, Annals of oncology : official journal of the European Society for Medical Oncology, Oct 2009
  • Correlating gene and protein expression data using Correlated Factor Analysis. Tan, CS, Salim, A, Ploner, A, Lehtiö, J, Chia, KS, Pawitan, Y, BMC bioinformatics, Sep 2009
  • Use of narrow-range peptide IEF to improve detection of lung adenocarcinoma markers in plasma and pleural effusion. Pernemalm, M, De Petris, L, Eriksson, H, Brandén, E, Koyi, H, Kanter, L, Lewensohn, R, Lehtiö, J, Proteomics, Jul 2009
  • Proteomics and pathway analysis identifies JNK signaling as critical for high linear energy transfer radiation-induced apoptosis in non-small lung cancer cells. Ståhl, S, Fung, E, Adams, C, Lengqvist, J, Mörk, B, Stenerlöw, B, Lewensohn, R, Lehtiö, J, Zubarev, R, Viktorsson, K, Molecular & cellular proteomics : MCP, May 2009
  • Robustness and accuracy of high speed LC-MS separations for global peptide quantitation and biomarker discovery. Lengqvist, J, Andrade, J, Yang, Y, Alvelius, G, Lewensohn, R, Lehtiö, J, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, May 2009
  • Tumor expression of S100A6 correlates with survival of patients with stage I non-small-cell lung cancer. De Petris, L, Orre, LM, Kanter, L, Pernemalm, M, Koyi, H, Lewensohn, R, Lehtiö, J, Lung cancer (Amsterdam, Netherlands), Mar 2009
  • Affinity prefractionation for MS-based plasma proteomics. Pernemalm, M, Lewensohn, R, Lehtiö, J, Proteomics, Mar 2009
  • Quantitative membrane proteomics applying narrow range peptide isoelectric focusing for studies of small cell lung cancer resistance mechanisms. Eriksson, H, Lengqvist, J, Hedlund, J, Uhlén, K, Orre, LM, Bjellqvist, B, Persson, B, Lehtiö, J, Jakobsson, PJ, Proteomics, Aug 2008
  • Evaluation of three principally different intact protein prefractionation methods for plasma biomarker discovery. Pernemalm, M, Orre, LM, Lengqvist, J, Wikström, P, Lewensohn, R, Lehtiö, J, Journal of proteome research, Jul 2008
  • Proteomic data analysis workflow for discovery of candidate biomarker peaks predictive of clinical outcome for patients with acute myeloid leukemia. Forshed, J, Pernemalm, M, Tan, CS, Lindberg, M, Kanter, L, Pawitan, Y, Lewensohn, R, Stenke, L, Lehtiö, J, Journal of proteome research, Jun 2008
  • Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics. Nordström, A, Want, E, Northen, T, Lehtiö, J, Siuzdak, G, Analytical chemistry, Jan 2008
  • Up-regulation, modification, and translocation of S100A6 induced by exposure to ionizing radiation revealed by proteomics profiling. Orre, LM, Pernemalm, M, Lengqvist, J, Lewensohn, R, Lehtiö, J, Molecular & cellular proteomics : MCP, Dec 2007
  • Proteomics in clinical prostate research. Hellström, M, Jonmarker, S, Lehtiö, J, Auer, G, Egevad, L, Proteomics. Clinical applications, Sep 2007
  • iTRAQ compatibility of peptide immobilized pH gradient isoelectric focusing. Lengqvist, J, Uhlén, K, Lehtiö, J, Proteomics, Jun 2007
  • Pre-fractionation of archival frozen tumours for proteomics applications. Forsberg, L, Larsson, C, Sofiadis, A, Lewensohn, R, Höög, A, Lehtiö, J, Journal of biotechnology, Dec 2006
  • Annotated regions of significance of SELDI-TOF-MS spectra for detecting protein biomarkers. Tan, CS, Ploner, A, Quandt, A, Lehtiö, J, Pernemalm, M, Lewensohn, R, Pawitan, Y, Proteomics, Dec 2006
  • Finding regions of significance in SELDI measurements for identifying protein biomarkers. Tan, CS, Ploner, A, Quandt, A, Lehtiö, J, Pawitan, Y, Bioinformatics (Oxford, England), Jun 2006
  • p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line. Orre, LM, Stenerlöw, B, Dhar, S, Larsson, R, Lewensohn, R, Lehtiö, J, Biochemical and biophysical research communications, Apr 2006
  • The binding specificity and affinity determinants of family 1 and family 3 cellulose binding modules. Lehtiö, J, Sugiyama, J, Gustavsson, M, Fransson, L, Linder, M, Teeri, TT, Proceedings of the National Academy of Sciences of the United States of America, Jan 2003
  • Engineering of staphylococcal surfaces for biotechnological applications. Wernérus, H, Lehtiö, J, Samuelson, P, Ståhl, S, Journal of biotechnology, Jun 2002
  • Generation of metal-binding staphylococci through surface display of combinatorially engineered cellulose-binding domains. Wernérus, H, Lehtiö, J, Teeri, T, Nygren, PA, Ståhl, S, Applied and environmental microbiology, Oct 2001
  • Stable linker peptides for a cellulose-binding domain-lipase fusion protein expressed in Pichia pastoris. Gustavsson, M, Lehtiö, J, Denman, S, Teeri, TT, Hult, K, Martinelle, M, Protein engineering, Sep 2001
  • Directed immobilization of recombinant staphylococci on cotton fibers by functional display of a fungal cellulose-binding domain. Lehtiö, J, Wernérus, H, Samuelson, P, Teeri, TT, Ståhl, S, FEMS microbiology letters, Feb 2001
  • Alpha-amylase inhibitors selected from a combinatorial library of a cellulose binding domain scaffold. Lehtiö, J, Teeri, TT, Nygren, PA, Proteins, Nov 2000
  • Trichoderma reesei cellobiohydrolase I with an endoglucanase cellulose-binding domain: action on bacterial microcrystalline cellulose. Srisodsuk, M, Lehtiö, J, Linder, M, Margolles-Clark, E, Reinikainen, T, Teeri, TT, Journal of biotechnology, Sep 1997