Towards improved medicine through MS
We are Lehtiö lab. We engage in developing mass spectrometry based methods to improve the depth of proteome analysis. Additionally, we apply multilayer bioinformatic analyses to examine the proteome in the context of the genome and transcriptome. Interpreting multilevel “omics” data provides an understanding of how genome aberrations impact the proteome. We apply this understanding to identify biomarkers which aid in selecting the most effective therapies for cancer patients. Check out positions and courses, read our publications, have a look at our services and instruments, and get in touch!

Selected publications

Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal.

Nature Medicine, Jul 2020
Tamborero, D., Dienstmann, R., Rachid, M.H., Boekel, J., Baird, R., Braña, I., De Petris, L., Yachnin, J., Massard, C., Opdam, F.L., Schlenk, R., Vernieri, C., Garralda, E., Masucci, M., Villalobos, X., Chavarria, E., Cancer Core Europe consortium, Calvo, F., Fröhling, S., Eggermont, A., Apolone, G., Voest, E.E., Caldas, C., Tabernero, J., Ernberg, I., Rodon, J., Lehtiö, J.

In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta.

eLife, Apr 2019
Pernemalm, M., Sandberg, A., Zhu, Y., Boekel, J., Tamburro, D., Schwenk, J.M., Bjork, A., Wahren-Herlenius, M., Amark, H., Ostenson, C.-G., Westgren, M., Lehtiö, J.

Breast cancer quantitative proteome and proteogenomic landscape.

Nature communications, Apr 2019
Johansson, H.J., Socciarelli, F., Vacanti, N.M., Haugen, M.H., Zhu, Y., Siavelis, I., Fernandez-Woodbridge, A., Aure, M.R., Sennblad, B., Vesterlund, M., Branca, R.M., Orre, L.M., Huss, M., Fredlund, E., Beraki, E., Garred, Ø., Boekel, J., Sauer, T., Zhao, W., Nord, S., Höglander, E.K., Jans, D.C., Brismar, H., Haukaas, T.H., Bathen, T.F., Schlichting, E., Naume, B., Geisler, J., Hofvind, S., Engebråten, O., Geitvik, G.A., Langerød, A., Kåresen, R., Mælandsmo, G.M., Sørlie, T., Skjerven, H.K., Park, D., Hartman-Johnsen, O.-J., Lüders, T., Borgen, E., Kristensen, V.N., Russnes, H.G., Lingjærde, O.C., Mills, G.B., Sahlberg, K.K., Børresen-Dale, A.-L., Lehtiö, J.

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.

Nature communications, Apr 2019
Yang, M, Vesterlund, M, Siavelis, I, Moura-Castro, LH, Castor, A, Fioretos, T, Jafari, R, Lilljebjörn, H, Odom, DT, Olsson, L, Ravi, N, Woodward, EL, Harewood, L, Lehtiö, J, Paulsson, K.

SubCellBarCode: Proteome-wide Mapping of Protein Localization and Relocalization.

Molecular Cell, Jan 2019
Orre LM, Vesterlund M, Pan Y, Arslan T, Zhu Y, Fernandez Woodbridge A, Frings O, Fredlund E, Lehtiö J.

Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow.

Nature communications, Mar 2018
Zhu, Y, Orre, LM, Johansson, HJ, Huss, M, Boekel, J, Vesterlund, M, Fernandez-Woodbridge, A, Branca, RMM, Lehtiö, J

Isoelectric point-based fractionation by HiRIEF coupled to LC-MS allows for in-depth quantitative analysis of the phosphoproteome.

Scientific reports, Jul 2017
Panizza, E, Branca, RMM, Oliviusson, P, Orre, LM, Lehtiö, J

Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis.

Nucleic acids research, Mar 2017
Zhu, Y, Engström, PG, Tellgren-Roth, C, Baudo, CD, Kennell, JC, Sun, S, Billmyre, RB, Schröder, MS, Andersson, A, Holm, T, Sigurgeirsson, B, Wu, G, Sankaranarayanan, SR, Siddharthan, R, Sanyal, K, Lundeberg, J, Nystedt, B, Boekhout, T, Dawson, TL, Heitman, J, Scheynius, A, Lehtiö, J

Multi-omic data analysis using Galaxy.

Nature biotechnology, Feb 2015
Boekel, J, Chilton, JM, Cooke, IR, Horvatovich, PL, Jagtap, PD, Käll, L, Lehtiö, J, Lukasse, P, Moerland, PD, Griffin, TJ

SpliceVista, a tool for splice variant identification and visualization in shotgun proteomics data.

Molecular & cellular proteomics : MCP, Jun 2014
Zhu, Y, Hultin-Rosenberg, L, Forshed, J, Branca, RM, Orre, LM, Lehtiö, J

HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics.

Nature methods, Jan 2014
Branca, RM, Orre, LM, Johansson, HJ, Granholm, V, Huss, M, Pérez-Bercoff, Å, Forshed, J, Käll, L, Lehtiö, J

Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer.

Nature communications, Jan 2013
Johansson, HJ, Sanchez, BC, Mundt, F, Forshed, J, Kovacs, A, Panizza, E, Hultin-Rosenberg, L, Lundgren, B, Martens, U, Máthé, G, Yakhini, Z, Helou, K, Krawiec, K, Kanter, L, Hjerpe, A, Stål, O, Linderholm, BK, Lehtiö, J

S100A4 interacts with p53 in the nucleus and promotes p53 degradation.

Oncogene, Dec 2013
Orre, LM, Panizza, E, Kaminskyy, VO, Vernet, E, Gräslund, T, Zhivotovsky, B, Lehtiö, J